patient had a history of similar lesions and it was excised leaving scar ( white arrow). A biosy was taken ( black arrow)
Primary cutaneous plasmacytoma is a rare B-cell lymphoma consisting of a monoclonal proliferation of mature plasma cells in the skin without underlying multiple myeloma.
* Localized forms of malignant proliferations of plasma cells include;
1- Solitary plasmacytoma of bone
2- Extramedullary plasmacytoma
* The term plasmacytoma is no longer used in the WHO-EORTC classification.
** PCP Originally classified as a discrete entity,currently is considered to be a variant of primary cutaneous marginal zone B-cell lymphoma.
* Cases of localization to the skin are thought
to represent 2% to 4% of all primary extramedullary plasmacytomas.
* Very few cases of PCPs ( 30) have been
reported in the literature
* Secondary cutaneous plasmacytoma occurs in the setting of multiple myeloma or extramedullary plasmacytoma.
* PCPs occur in age range of 22 to 88 years
* lesions typically present as slow-growing, reddish brown macules or plaques on the face, trunk, or extremities.
Multiple myeloma developed in one-third of patients & the features include;
1- Bone marrow plasmacytosis of more than 10%
2- Osteolytic lesions
3- Detection of a plasma or urine paraprotein.
( all were normal in our patient)
1- Other primary B cell lymphoma
2- Benign infiltrates of plasma cells in the skin (eg, plasma cell granuloma)
3- Infectious diseases with prominent plasma cell infiltration (eg, syphilis, borrelia infection)
* Patients with solitary lesions have a better prognosis than those with multiple lesions.
* Possible treatment options include;
1- Intralesional steroids
3- Topical immunomodulators
4- local radiotherapy